Prevencion de accidente cerebrovascular en anemia de celulas falciformes

	Hematology Am Soc Hematol Educ Program. 2006:54-7. Prevention and management of stroke in sickle cell anemia. Platt OS. Children's Hospital Boston, Boston MA 02115, USA. orah.platt@childrens.harvard.edu Abstract As the overall health of patients with sickle cell anemia (SS) improves and diagnostic techniques become more sensitive, physicians are seeing patients with an increasingly wide range of subtle and not-so-subtle brain injury. The major breakthrough in the field of sickle-related brain injury has been the unprecedented success of transcranial Doppler ultrasonography (TCD) to identify asymptomatic patients at high risk of stroke, coupled with chronic transfusion therapy to prevent it. The evidence for TCD screening and preventive treatment is strong and compelling, but there are still important unanswered questions regarding the implications of "silent infarcts" found in the magnetic resonance images (MRIs) of asymptomatic individuals, and the growing awareness of the burden of neuropsychiatric dysfunction in otherwise apparently healthy individuals. Free Article
	PMID: 17124040 [PubMed - indexed for MEDLINE]